One of the most fundamental tenets of toxicology is that "the dose determines the poison." This simple phrase provides the basis for the belief that all agents—chemicals and physical phenomena that are capable of producing some effect—have the potential to cause toxicity. Whether toxicity actually occurs is principally a matter of dose: the greater the exposure to a given agent, the more pronounced or severe the response of a cell or organism.

Offshore areas are under pressure to industrialize for renewable energy. To plan for offshore wind development, Rhode Island engaged in a marine spatial planning process that resulted in the Ocean Special Area Management Plan (O-SAMP), a regulatory invention of the Coastal Zone Management Act. Notably, the Rhode Island O-SAMP maps and plans for uses in federal waters beyond the three-mile line dividing state and fedeal jurisdiction, as well as within the state's territorial sea, posing a challenge to the boundaries of offshore federalism.