Several key issues have emerged as pivotal in ongoing efforts to reform the Toxic Substances Control Act (TSCA). Progress on these complex issues is central to the success of TSCA reform. To foster further discussion of these critical topics, ELI convened a series of issue-specific webinars during the summer and fall of 2011 that provided a forum for focused dialogue among key players. On November 30, 2011, ELI brought together a panel to examine reform of EPA authorities to control the sale, distribution, releases, and use of chemicals. Topics addressed included standard of proof, the role of cost/benefit analysis, private firm obligations, approaches to new technologies such as nanotech, and the role of downstream users of chemicals.